The efficacy of Royal Jelly in the restoration of alcoholic liver injury in mouse model

Prolonged excessive ingestion or consumption of alcohol eventually results in hepatic insufficiency; induces the aggravation of viral hepatitis and/or fatty liver. The long term ingestion of alcohol not only induces a decline in the immune function but also promotes the production of inflammatory cytokines by Kupffer cells activated by enterobacterial endotoxins. Royal Jelly has numerous functions, such as for the maintenance of health, immunopotentiation and age-retarding etc. Furthermore, Royal Jelly functions as a potent immunomodulator, such as Royal Jelly ameliorates stress-associated immune dysfunction. An alcoholic hepatic insufficiency mouse model was constructed by feeding it a liquid diet containing 5 % ethanol and features of the innate immune system were observed to assess whether Royal Jelly has any effect on alcohol-induced liver insufficiency. The data reveal that Royal Jelly administration (1) exhibits prophylactic effect on alcohol-induced hepatomegaly and (2) functions in restoration of transaminase levels caused by impaired hepatocytes. Royal Jellymodulated important immune phenomena on alcoholic liver injury include (1) activation of liver natural killer cells and (2) control of the levels of IL-4, IL-5, and TNF-alpha in the serum. These findings provide evidence that Royal Jelly might have the capacity to restore the function of the immune system in individuals with alcoholic liver diseases.